64223-54-7
64223-54-7
Chemical Structure
Pyramidatine
Synonym(s): Haplamidine
- CAS No.: 64223-54-7
- Formula:C20H22N2O2
- Molecular Weight:322.41
IUPAC Name: N-(4-cinnamamidobutyl)benzamide
InChIKey: XYVZRTYPQHUZGY-BUHFOSPRSA-N
SMILES: C(NCCCCNC(/C=C/C1=CC=CC=C1)=O)(=O)C2=CC=CC=C2
Biological Activity: Pyramidatine (Haplamidine) is a P-glycoprotein inhibitor with an IC50 of 39.29 µM. As a sensitizer, Pyramidatine enhances Vincristine (HY-N0488A)-induced Apoptosis and G2/M phase arrest, while potentiating the activity of Vincristine against drug-resistant oral cancer. Pyramidatine can be used in research related to oral cancer and mammary adenocarcinoma[1][2].
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Pyramidatine | Pyramidatine (Haplamidine) is a P-glycoprotein inhibitor with an IC50 of 39.29 µM. As a sensitizer, Pyramidatine enhances Vincristine (HY-N0488A)-induced Apoptosis and G2/M phase arrest, while potentiating the activity of Vincristine against drug-resistant oral cancer. Pyramidatine can be used in research related to oral cancer and mammary adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Liu Z, et al. Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein. Anti-cancer agents in medicinal chemistry. 2018;18(2):286-294. [Content Brief]
- [2]. Saifah E, et al. Bisamides from Aglaia species: structure analysis and potential to reverse drug resistance with cultured cells. Journal of natural products. 1993 Apr;56(4):473-7. [Content Brief]
