64544-24-7
64544-24-7
Chemical Structure
Moclobemide N-Oxide
Synonym(s): Ro 12-5637
- CAS No.: 64544-24-7
- Formula:C13H17ClN2O3
- Molecular Weight:284.74
IUPAC Name: 4-(2-(4-chlorobenzamido)ethyl)morpholine 4-oxide
InChIKey: CJTZZADPEGGIMM-UHFFFAOYSA-N
SMILES: O=C(NCC[N+]1([O-])CCOCC1)C2=CC=C(Cl)C=C2
Biological Activity: Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm[1][2].
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Moclobemide N-Oxide | Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm. | |||||||||||||||||||||
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References
- [1]. Rakic Ignjatovic A, et al. Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study. Br J Clin Pharmacol. 2009 Feb;67(2):199-208. [Content Brief]
- [2]. Geschke R, et al. Determination of the new monoamine oxidase inhibitor moclobemide and three of its metabolites in biological fluids by high-performance liquid chromatography. J Chromatogr. 1987 Sep 4;420(1):111-20. [Content Brief]
Keywords
