64748-79-4
64748-79-4
Chemical Structure
Azumolene
Synonym(s): EU4093 free base
- CAS No.: 64748-79-4
- Formula:C13H9BrN4O3
- Molecular Weight:349.14
IUPAC Name: (E)-1-(((5-(4-bromophenyl)oxazol-2-yl)methylene)amino)imidazolidine-2,4-dione
InChIKey: SEGCNGONCZQFDW-OMCISZLKSA-N
SMILES: O=C1NC(CN1/N=C/C2=NC=C(C3=CC=C(Br)C=C3)O2)=O
Biological Activity: Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2].
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Azumolene | 99.11% | Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research. | ||||||||||||||||||||
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References
- [1]. G C Leslie, et al. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br J Pharmacol. 1989 Aug;97(4):1151-6. [Content Brief]
- [2]. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633. [Content Brief]
