64838-55-7
64838-55-7
Chemical Structure
Captopril EP Impurity J
Synonym(s): S-Acetylcaptopril
- CAS No.: 64838-55-7
- Formula:C11H17NO4S
- Molecular Weight:259.32
IUPAC Name: ((S)-3-(acetylthio)-2-methylpropanoyl)-L-proline
InChIKey: ZNQRGUYIKSRYCI-APPZFPTMSA-N
SMILES: O=C([C@H]1N(C([C@H](C)CSC(C)=O)=O)CCC1)O
Biological Activity: Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
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Captopril EP Impurity J | Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM). | |||||||||||||||||||||
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References
- [1]. Li, Hp, et al. Synthesis and characterization of captopril derivatives. Res Chem Intermed 39, 621–629 (2013).
- [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [Content Brief]
- [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35. [Content Brief]
Keywords
