6508-43-6
6508-43-6
Chemical Structure
L 152804
- CAS. Nr.: 6508-43-6
- Formula:C23H26O4
- Molecular Weight:366.45
IUPAC Name: 2-(3,3-dimethyl-1-oxo-2,3,4,9-tetrahydro-1H-xanthen-9-yl)-5,5-dimethylcyclohexane-1,3-dione
InChIKey: XQDXIHYKAGHZRX-UHFFFAOYSA-N
SMILES: O=C1C2=C(CC(C)(C)C1)OC3=CC=CC=C3C2C4C(CC(C)(C)CC4=O)=O
Biological Activity: L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2].
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L 152804 | 99.89% | L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. | ||||||||||||||||||||
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L 152804 (Standard) | L 152804 (Standard) is the analytical standard of L 152804 (HY-107734). This product is intended for research and analytical applications. L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. | |||||||||||||||||||||
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References
- [1]. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73. [Content Brief]
- [2]. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14. [Content Brief]
Keywords
