65854-97-9
65854-97-9
Chemical Structure
Phenytoin-d10
Synonym(s): 5,5-Diphenylhydantoin-d10
- CAS No.: 65854-97-9
- Formula:C15H2D10N2O2
- Molecular Weight:262.33
IUPAC Name: 5,5-bis(phenyl-d5)imidazolidine-2,4-dione
InChIKey: CXOFVDLJLONNDW-LHNTUAQVSA-N
SMILES: O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC(N1)=O
Biological Activity: Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].
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Phenytoin-d10 | 99.50% | Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Phenytoin (Standard) | 99.94% | Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Phenytoin-d5 | Phenytoin-d5 (5,5-Diphenylhydantoin-d5) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | |||||||||||||||||||||
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Phenytoin-15N2,13C | 99.84% | Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. The product specifications provided below refer solely to the active content of Phenytoin-15N2,13C. |
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Phenytoin | 99.95% | Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.85
HY-1456715-(3-hydroxyphenyl)-5-phenylhydantoin -
Similarity Score 0.78
HY-W7214025-Phenyl-5-(phenyl-d5)imidazolidine-2,4-dione -
Similarity Score 0.77
HY-132948S5-(4-Hydroxyphenyl)-5-phenyl hydantoin-15N2,d5 -
Similarity Score 0.77
HY-141857S5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-2,4,5-13C3 -
Similarity Score 0.75
HY-1215955,5-Diphenylbarbituric acid -
Similarity Score 0.73
HY-B0448ARPhenytoin sodium (Standard) -
Similarity Score 0.66
HY-B1657Fosphenytoin -
Similarity Score 0.65
HY-137258(±)-N-3-Benzylnirvanol -
Similarity Score 0.65
HY-137258A(R)-N-3-Benzylnirvanol -
Explore the MedChemAI to find more analogs
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13. [Content Brief]
