660846-41-3
660846-41-3
Chemical Structure
GW542573X
- CAS. Nr.: 660846-41-3
- Formula:C19H28N2O5
- Molecular Weight:364.44
IUPAC Name: tert-butyl 4-((((2-methoxyphenyl)carbamoyl)oxy)methyl)piperidine-1-carboxylate
InChIKey: SAXGSDIZIYFNKD-UHFFFAOYSA-N
SMILES: O=C(N1CCC(COC(NC2=CC=CC=C2OC)=O)CC1)OC(C)(C)C
Biological Activity: GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].
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GW542573X | 99.79% | GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-W099109tert-Butyl 4-(4-(ethoxycarbonyl)phenoxy)piperidine-1-carboxylate -
Similarity Score 0.59
HY-164714HSL-IN-5 -
Similarity Score 0.58
HY-W102095tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate -
Similarity Score 0.58
HY-W3983423-(4-((1-(Tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)propanoic acid -
Similarity Score 0.58
HY-W107433tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate -
Similarity Score 0.58
HY-W090887tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate -
Similarity Score 0.56
HY-W001461tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate -
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References
- [1]. Hougaard C, et, al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. 2009 Sep;76(3):569-78. [Content Brief]
