6709-57-5
Chemical Structure
Linoleoyl-CoA
Synonym(s): Linoleoyl Coenzyme A; 9(Z),12(Z)-Octadecadienoyl Coenzyme A; 9Z,12Z-Octadecadienoyl-CoA; 9Z,12Z-Octadecadienoyl-coenzyme A
- CAS No.: 6709-57-5
- Formula:C39H66N7O17P3S
- Molecular Weight:1029.96
InChIKey: YECLLIMZHNYFCK-RRNJGNTNSA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O)(O)=O)(O)=O)O3
Biological Activity: Linoleoyl-CoA (Linoleoyl Coenzyme A) is a long-chain acyl-CoA ester formed from linoleic acid and coenzyme A. Linoleoyl-CoA serves as a key activated fatty acid intermediate involved in lipid biosynthesis, fatty acid β-oxidation and the regulation of cellular metabolism. Elevated levels of Linoleoyl-CoA in skeletal muscle correlate with increased lipid availability, insulin resistance and metabolic dysregulation and can be used for activity assays of acyl-CoA synthetases, acyltransferases and fatty acid metabolic enzymes[1][2][3].
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Linoleoyl-CoA | Linoleoyl-CoA (Linoleoyl Coenzyme A) is a long-chain acyl-CoA ester formed from linoleic acid and coenzyme A. Linoleoyl-CoA serves as a key activated fatty acid intermediate involved in lipid biosynthesis, fatty acid β-oxidation and the regulation of cellular metabolism. Elevated levels of Linoleoyl-CoA in skeletal muscle correlate with increased lipid availability, insulin resistance and metabolic dysregulation and can be used for activity assays of acyl-CoA synthetases, acyltransferases and fatty acid metabolic enzymes. | |||||||||||||||||||||
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References
- [1]. Smith PB, et al. Acyl-CoA synthase and acyltransferase activity in developing skeletal muscle membranes. Biochimica et biophysica acta. 1982 Oct 14;713(1):128-35. [Content Brief]
- [2]. Stymne S, et al. The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds. European journal of biochemistry. 1978 Oct;90(2):223-9.
- [3]. Ellis BA, et al. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. American journal of physiology. Endocrinology and metabolism. 2000 Sep;279(3):E554-60.
