674767-29-4
Chemical Structure
CG-1521
- CAS. Nr.: 674767-29-4
- Formula:C13H13NO2
- Molecular Weight:215.25
IUPAC Name: (2E,4E,6E)-N-hydroxy-7-phenylhepta-2,4,6-trienamide
InChIKey: DBBYYRWVNDQECM-CDWOPPGASA-N
SMILES: C(=C/C=C/C=C/C(NO)=O)\C1=CC=CC=C1
Biological Activity: CG-1521 is a histone deacetylase (HDAC) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation. CG-1521 can inhibit proliferation, induce cell cycle arrest and apoptosis. CG-1521 promotes Bax translocation to the mitochondria and cleavage. CG-1521 downregulates KIF4, Aurora B and Nek2 protein expression and DNA synthesis. CG-1521 can be used for the research of prostate cancer and inflammatory breast cancer[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CG-1521 | 95.71% | CG-1521 is a histone deacetylase (HDAC) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation. CG-1521 can inhibit proliferation, induce cell cycle arrest and apoptosis. CG-1521 promotes Bax translocation to the mitochondria and cleavage. CG-1521 downregulates KIF4, Aurora B and Nek2 protein expression and DNA synthesis. CG-1521 can be used for the research of prostate cancer and inflammatory breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Roy S, et al. Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. Mol Cancer Ther. 2008;7(7):1931-1939. [Content Brief]
- [2]. Chatterjee N, et al. Molecular actions of the novel histone deacetylase inhibitor CG-1521 in models of inflammatory breast cancer[J]. 2014.
- [3]. Roy S, et al. Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. Cell Death Differ. 2005;12(5):482-491. [Content Brief]
