68207-21-6
Chemical Structure
FD44
- CAS No.: 68207-21-6
- Formula:C19H21N3OS
- Molecular Weight:339.45
IUPAC Name: N-(10H-phenothiazin-10-yl)-2-(piperidin-1-yl)acetamide
InChIKey: ALVVXSSFOOYRDP-UHFFFAOYSA-N
SMILES: O=C(CN1CCCCC1)NN2C3=C(SC4=C2C=CC=C4)C=CC=C3
Biological Activity: FD44 is a phenothiazine small molecule that inhibits the interaction between neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor Ric8a, a key regulator of synapse number and neurotransmitter release probability. In the Drosophila genetic autism model of fragile X syndrome (FXS), FD44 restored normal synapse number and associative learning[1].
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FD44 | FD44 is a phenothiazine small molecule that inhibits the interaction between neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor Ric8a, a key regulator of synapse number and neurotransmitter release probability. In the Drosophila genetic autism model of fragile X syndrome (FXS), FD44 restored normal synapse number and associative learning. | |||||||||||||||||||||
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Keywords
