682763-67-3
Chemical Structure
BF-158
- CAS No.: 682763-67-3
- Formula:C16H14N2
- Molecular Weight:234.30
IUPAC Name: N-methyl-4-(quinolin-2-yl)aniline
InChIKey: SLVJLLSYTZXMFL-UHFFFAOYSA-N
SMILES: CNC1=CC=C(C=C1)C2=NC3=C(C=C2)C=CC=C3
Biological Activity: BF-158 is a quinoline-based Tau Protein fluorescent imaging probe that produces specific staining by recognizing the β-sheet structure of paired helical filaments (PHF)/neurofibrillary tangles (NFT) in tau aggregates, with EC50 values of 399 nM and 659 nM for tau fibrils and Aβ1-42 fibrils, respectively. BF-158 preferentially labels NFTs, neuropil threads, and PHF-type neurites. BF-158 is useful for the study and imaging of tau pathology in Alzheimer's disease[1][2].
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BF-158 | BF-158 is a quinoline-based Tau Protein fluorescent imaging probe that produces specific staining by recognizing the β-sheet structure of paired helical filaments (PHF)/neurofibrillary tangles (NFT) in tau aggregates, with EC50 values of 399 nM and 659 nM for tau fibrils and Aβ1-42 fibrils, respectively. BF-158 preferentially labels NFTs, neuropil threads, and PHF-type neurites. BF-158 is useful for the study and imaging of tau pathology in Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Declercq L, et al. Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807. Molecular imaging. 2016;15:1536012115624920.
- [2]. Okamura N, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Nov 23;25(47):10857-62. [Content Brief]
