684-93-5
684-93-5
Chemical Structure
N-Nitroso-N-methylurea
- CAS No.: 684-93-5
- Formula:C2H5N3O2
- Molecular Weight:103.08
IUPAC Name: 1-methyl-1-nitrosourea
InChIKey: ZRKWMRDKSOPRRS-UHFFFAOYSA-N
SMILES: O=C(N)N(C)N=O
Biological Activity: N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
N-Nitroso-N-methylurea | 99.74% | N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-Nitroso-N-methylurea-d5 | N-Nitroso-N-methylurea-d5 is the deuterium labeled N-Nitroso-N-methylurea (HY-34758). N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sarcosinamide chloroethylnitrosourea | Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent. Sarcosinamide chloroethylnitrosourea can induce apoptosis by promoting DNA alkylation. Sarcosinamide chloroethylnitrosourea can be used in cancer-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methylnitronitrosoguanidine | 99.97% | Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen. 50% water content, specifications are based on dry weight. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Propionamide | 99.73% | Propionamide is a saturated amide small molecule compound. Propionamide can be used to assist in the mechanistic research of BTK covalent inhibitors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-Ethyl-N-nitrosourea | 99.94% | N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methoxyurea | Methoxyurea (Compound 3) is a potential regulator of nitric oxide (NO) donors that acts on hemoglobins such as oxy-hemoglobin (OxyHb) and met-hemoglobin (MetHb). Methoxyurea is promising for research of sickle cell disease (SCD). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-Mitrososarcosine | N-Nitrososarcosine is a nitrosation product of Sarcosine (HY-101037) and can be found in cured meat products. N-Nitrososarcosine (225 mg/kg) induces the formation of metastatic liver carcinomas in mice. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-nitroso-n-methylurethane (Standard) | ≥98% | N-nitroso-n-methylurethane (Standard) is the analytical standard of N-nitroso-n-methylurethane. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-Methyl-N-nitroso-2-propanamine | N-Methyl-N-nitroso-2-propanamine is an N-nitrosamine, which induces tumor formation in mice. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dimethynur | Dimethynur is an anti-tumor agent. Dimethynur exerts anti-tumor effects in solid sarcoma mouse models. Dimethynur can be used in cancer research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N,N-Dimethylamidino Urea | 98.78% | N,N-Dimethylamidino Urea (N-Carbonylguanidine) is an intermediate in the electrochemical oxidation of Metformin (HY-B0627). Metformin can be used in the study of type 2 diabetes. N,N-Dimethylamidino Urea can be used as a marker to study the metabolic pathway of metformin in vivo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Gullino PM, et al. N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst. 1975 Feb;54(2):401-14. [Content Brief]
- [2]. Tsubura A, et al. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011 Jan-Feb;25(1):11-22. [Content Brief]
- [3]. Johnson EM, et al. Effects of N-nitroso-N-methylurea on enzymatic ontogeny associated with teratogenesis. Teratology. 1968 May;1(2):179-91. [Content Brief]
- [4]. Silvia Garbarino, et al. One-pot synthesis of α-haloketones employing a membrane-based semibatch diazomethane generator. Journal of Flow Chemistry volume 6, pages211-217(2016).
