6878-36-0
Chemical Structure
Echitamine chloride
Synonym(s): Ditaine chloride
- CAS No.: 6878-36-0
- Formula:C22H29ClN2O4
- Molecular Weight:420.93
IUPAC Name: (1S,3S,8aS,13aR,14R,E)-4-ethylidene-1-hydroxy-14-(hydroxymethyl)-14-(methoxycarbonyl)-6-methyl-1,2,3,4,5,6,7,8-octahydro-13H-3,8a-methanoazepino[1',2':1,2]pyrrolo[2,3-b]indol-6-ium chloride
InChIKey: QYXFKPCRGWUWAM-KKWFITTBSA-M
SMILES: O=C([C@@]([C@@](C1=CC=CC=C1N2)(CC3)[C@]2([C@H]4O)[N+]3(C/C5=C/C)C)([C@H]5C4)CO)OC.[Cl-]
Biological Activity: Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 μM[1][2].
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Echitamine chloride | 98.0% | Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 μM. | ||||||||||||||||||||
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References
- [1]. Ganesh Chandra Jagetia, et al. Evaluation of the Cytotoxic Effect of the Monoterpene Indole Alkaloid Echitamine In-Vitro and in Tumour-Bearing Mice. J Pharm Pharmacol. 2005 Sep;57(9):1213-9. [Content Brief]
- [2]. Ginson George, et al. Development and Validation of a New HPTLC-HRMS Method for the Quantification of a Potent Pancreatic Lipase Inhibitory Lead Echitamine From Alstonia scholaris. Nat Prod Res. 2019 Dec 24;1-5. [Content Brief]
