691862-35-8
691862-35-8
Chemical Structure
CdnP-IN-1
- CAS No.: 691862-35-8
- Formula:C17H17N3O3S
- Molecular Weight:343.40
InChIKey: JHEASKMQXRYFDN-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=CN1CC(NC3=C(OC)C=CC=C3)=O)SC(CC)=C2
Biological Activity: CdnP-IN-1 (compound c82) is a potent and selective non-nucleotide MTB CDN PDE (CdnP; Mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase) inhibitor with an IC50 of 18 μM. CdnP-IN-1 does not inhibit the enzymatic activities of three other bacterial CDN PDEs (Yybt, RocR, and GBS-CdnP), a viral CDN PDE (poxin) or mammalian ENPP1[1].
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CdnP-IN-1 | CdnP-IN-1 (compound c82) is a potent and selective non-nucleotide MTB CDN PDE (CdnP; Mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase) inhibitor with an IC50 of 18 μM. CdnP-IN-1 does not inhibit the enzymatic activities of three other bacterial CDN PDEs (Yybt, RocR, and GBS-CdnP), a viral CDN PDE (poxin) or mammalian ENPP1. | |||||||||||||||||||||
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References
Keywords
