69610-41-9
69610-41-9
Chemical Structure
N-Boc-L-Prolinal
- CAS. Nr.: 69610-41-9
- Formula:C10H17NO3
- Molecular Weight:199.25
IUPAC Name: tert-butyl (S)-2-formylpyrrolidine-1-carboxylate
InChIKey: YDBPZCVWPFMBDH-QMMMGPOBSA-N
SMILES: O=C[C@H]1N(C(OC(C)(C)C)=O)CCC1
Biological Activity: N-Boc-L-Prolinal is a proline bearing a Boc protecting group and can be used to synthesize bioactive peptidomimetics. N-Boc-L-Prolinal can serve as an organic synthesis intermediate[1][2][3][4][5][6][7].
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N-Boc-L-Prolinal | N-Boc-L-Prolinal is a proline bearing a Boc protecting group and can be used to synthesize bioactive peptidomimetics. N-Boc-L-Prolinal can serve as an organic synthesis intermediate. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-W008201tert-Butyl 3-formylpyrrolidine-1-carboxylate -
Similarity Score 0.90
HY-W066517Atert-Butyl (S)-2-vinylpyrrolidine-1-carboxylate -
Similarity Score 0.86
HY-40102(S)-1-Boc-2-(aminomethyl)pyrrolidine -
Similarity Score 0.86
HY-78924N-Boc-D-prolinol -
Similarity Score 0.86
HY-789261-Boc-2-(S)-pyrrolidinemethanol -
Similarity Score 0.86
HY-40114Boc-L-proline -
Similarity Score 0.86
HY-40115N-Boc-D-proline -
Similarity Score 0.85
HY-69260tert-Butyl 4-formylpiperidine-1-carboxylate -
Similarity Score 0.81
HY-602181-Boc-3-(hydroxymethyl)pyrrolidine -
Explore the MedChemAI to find more analogs
References
- [1]. Wang X, et al. Synthesis and biological activity evaluation of dolastatin 10 analogues with N-terminal modifications. Tetrahedron. 2017 Apr 20;73(16):2255-66. [Content Brief]
- [2]. Bocci M, et al. In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment. Journal of controlled release : official journal of the Controlled Release Society. 2024 Mar;367:779-790. [Content Brief]
- [3]. Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T Trafficking into the Tumor Microenvironment. Journal of medicinal chemistry. 2019 Jul 11;62(13):6190-6213. [Content Brief]
- [4]. Chiba J, et al. Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist. Bioorganic & medicinal chemistry letters. 2005 Jan 03;15(1):41-5. [Content Brief]
- [5]. Wallén EA, et al. 4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors. Bioorganic & medicinal chemistry. 2002 Jul;10(7):2199-206.
- [6]. Podichetty AK, et al. Fluorinated isatin derivatives. Part 3. New side-chain fluoro-functionalized pyrrolidinyl sulfonyl isatins as potent caspase-3 and -7 inhibitors. Future medicinal chemistry. 2009 Aug;1(5):969-89.
- [7]. Gutman H, et al. Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization. ACS medicinal chemistry letters. 2021 Oct 14;12(10):1596-1604. [Content Brief]
