69685-22-9
Chemical Structure
Butaprost
- CAS No.: 69685-22-9
- Formula:C24H40O5
- Molecular Weight:408.57
IUPAC Name: methyl 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-4-hydroxy-4-(1-propylcyclobutyl)but-1-en-1-yl)-5-oxocyclopentyl)heptanoate
InChIKey: XRISENIKJUKIHD-IOOSKWMSSA-N
SMILES: COC(CCCCCC[C@@H](C(C[C@H]1O)=O)[C@H]1/C=C/C[C@@H](C2(CCC2)CCC)O)=O
Biological Activity:
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].
The product specifications provided below refer solely to the active content of Butaprost.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Butaprost | 99.85% | Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling. The product specifications provided below refer solely to the active content of Butaprost. |
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Similarity Score 0.91
HY-120973Butaprost free acid (0.5% in methyl acetate) -
Similarity Score 0.91
HY-120973A(S)-Butaprost free acid -
Similarity Score 0.77
HY-121091EP2 receptor agonist 4 -
Similarity Score 0.75
HY-13790811β-Misoprostol -
Similarity Score 0.71
HY-114942Prostaglandin E1 ethyl ester -
Similarity Score 0.71
HY-106074Mexiprostil -
Similarity Score 0.70
HY-138206Prostaglandin E1 isopropyl ester -
Similarity Score 0.70
HY-B0131AAlprostadil sodium -
Similarity Score 0.70
HY-118189Misoprostol acid -
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References
- [1]. Yanbin Liang, et al. Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription. Br J Pharmacol. 2004 Jun;142(4):737-48. [Content Brief]
- [2]. Michael Schou Jensen, et al. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta Physiol (Oxf). 2019 Sep;227(1):e13291. [Content Brief]
- [3]. K Tani, et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2025-8. [Content Brief]
