Design and synthesis of a highly selective EP2-receptor agonist

  • Bioorg Med Chem Lett. 2001 Aug 6;11(15):2025-8. doi: 10.1016/s0960-894x(01)00359-6.
K Tani  1 ,  A Naganawa ,  A Ishida ,  H Egashira ,  K Sagawa ,  H Harada ,  M Ogawa ,  T Maruyama ,  S Ohuchida ,  H Nakai ,  K Kondo ,  M Toda
Affiliations
  • 1. Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan. [email protected]
PMID: 11454472 DOI: 10.1016/s0960-894x(01)00359-6
Abstract

EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility.

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