71080-06-3
Chemical Structure
Timegadine hydrochloride
Synonym(s): SR1368 hydrochloride
- CAS No.: 71080-06-3
- Formula:C20H24ClN5S
- Molecular Weight:401.96
InChIKey: IWMWBGDREQGECL-UHFFFAOYSA-N
SMILES: CC1=NC2=C(C(/N=C(NC3CCCCC3)/NC4=NC=CS4)=C1)C=CC=C2.Cl
Biological Activity: Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine (HY-100125). Timegadine hydrochloride is an orally active inhibitor for COX and lipo-oxygenase, that inhibits COX in washed rabbit platelets and rat brain with IC50 of 5 nM and 20 μM, inhibits lipo-oxygenase in in horse and washed rabbit platelets with IC50 of 100 μM. Timegadine hydrochloride exhibits anti-arthritis activity[1].
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Timegadine hydrochloride | Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine (HY-100125). Timegadine hydrochloride is an orally active inhibitor for COX and lipo-oxygenase, that inhibits COX in washed rabbit platelets and rat brain with IC50 of 5 nM and 20 μM, inhibits lipo-oxygenase in in horse and washed rabbit platelets with IC50 of 100 μM. Timegadine hydrochloride exhibits anti-arthritis activity. | |||||||||||||||||||||
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