725246-18-4
Chemical Structure
(17R,18S)-Epoxyeicosatetraenoic acid
Synonym(s): 17(R),18(S)-EETeTr
- CAS No.: 725246-18-4
- Formula:C20H30O3
- Molecular Weight:318.45
IUPAC Name: (5Z,8Z,11Z,14Z)-16-((2R,3S)-3-ethyloxiran-2-yl)hexadeca-5,8,11,14-tetraenoic acid
InChIKey: GPQVVJQEBXAKBJ-VDTDYMMTSA-N
SMILES: OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C[C@@H]1[C@@H](O1)CC)=O
Biological Activity: (17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(17R,18S)-Epoxyeicosatetraenoic acid | 93.0% | (17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia. | ||||||||||||||||||||
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- [1]. Hercule HC, et al. The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents. Exp Physiol. 2007;92(6):1067-1076. [Content Brief]
- [2]. Falck JR, et al. 17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues. J Med Chem. 2011;54(12):4109-4118. [Content Brief]
- [3]. Schwarz D, et al. Human CYP1A1 variants lead to differential eicosapentaenoic acid metabolite patterns. Biochem Biophys Res Commun. 2005;336(3):779-783. [Content Brief]
Keywords
