7362-39-2
Chemical Structure
p-Coumaric Acid Ethyl Ester
Synonym(s): Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate
- CAS No.: 7362-39-2
- Formula:C11H12O3
- Molecular Weight:192.21
IUPAC Name: ethyl (E)-3-(4-hydroxyphenyl)acrylate
InChIKey: ZOQCEVXVQCPESC-VMPITWQZSA-N
SMILES: CCOC(/C=C/C1=CC=C(O)C=C1)=O
Biological Activity: p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a tyrosinase (Tyrosinase) inhibitor (IC50 = 4.89 μg/mL; Ki = 1.83 μg/mL). p-Coumaric Acid Ethyl Ester exhibits antitumor, antifungal, anti-inflammatory, and antioxidant activities. p-Coumaric Acid Ethyl Ester inhibits melanoma proliferation by inducing cell cycle arrest, and inhibits melanin synthesis by non-competitively altering tyrosinase conformation to hinder substrate binding. p-Coumaric Acid Ethyl Ester can be used in research on melanoma, whitening cosmetics, and fruit preservation[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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p-Coumaric Acid Ethyl Ester | 99.19% | p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a tyrosinase (Tyrosinase) inhibitor (IC50 = 4.89 μg/mL; Ki = 1.83 μg/mL). p-Coumaric Acid Ethyl Ester exhibits antitumor, antifungal, anti-inflammatory, and antioxidant activities. p-Coumaric Acid Ethyl Ester inhibits melanoma proliferation by inducing cell cycle arrest, and inhibits melanin synthesis by non-competitively altering tyrosinase conformation to hinder substrate binding. p-Coumaric Acid Ethyl Ester can be used in research on melanoma, whitening cosmetics, and fruit preservation. | ||||||||||||||||||||
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p-Coumaric Acid Ethyl Ester (Standard) | ≥98% | p-Coumaric Acid Ethyl Ester Standard (Ethyl (E)-p-hydroxycinnamate Standard; Ethyl trans-4-hydroxycinnamate Standard) is the analytical standard of p-Coumaric Acid Ethyl Ester (HY-N3103). This product is intended for research and analytical applications. p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a tyrosinase (Tyrosinase) inhibitor (IC50 = 4.89 μg/mL; Ki = 1.83 μg/mL). p-Coumaric Acid Ethyl Ester exhibits antitumor, antifungal, anti-inflammatory, and antioxidant activities. p-Coumaric Acid Ethyl Ester inhibits melanoma proliferation by inducing cell cycle arrest, and inhibits melanin synthesis by non-competitively altering tyrosinase conformation to hinder substrate binding. p-Coumaric Acid Ethyl Ester can be used in research on melanoma, whitening cosmetics, and fruit preservation. | ||||||||||||||||||||
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References
- [1]. Li L, et al. Tyrosinase inhibition by -coumaric acid ethyl ester identified from camellia pollen. Food science & nutrition. 2021 Jan;9(1):389-400. [Content Brief]
- [2]. Zengin G, et al. Chemical characterization and bioactive properties of different extracts from Fibigia clypeata, an unexplored plant food. Foods. 2020 Jun 1;9(6):705.
- [3]. Chen Y, et al. A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex. Nature communications. 2022 Jan 11;13(1):246.
- [4]. Zhu H, et al. Inhibition effects of Eucalyptus globules Labill. essential oil against tyrosinase. Scientific reports. 2025 May 09;15(1):16212.
- [5]. Tung BT, et al. In silico screening of phenolic acids as potential inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase. Journal of Molecular Chemistry. 2021 Feb 16;1(1):104-.
- [6]. Fernandes DC, et al. Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. Chemical & pharmaceutical bulletin. 2008 May;56(5):723-6. [Content Brief]
- [7]. Carmo-Martins JI, et al. Esterification of -Coumaric Acid Improves the Control over Melanoma Cell Growth. Biomedicines. 2023 Jan 12;11(1):196.
- [8]. Oh CM, et al. Identification of -Coumaric Acid and Ethyl -Coumarate as the Main Phenolic Components of Hemp ( L.) Roots. Molecules (Basel, Switzerland). 2022 Apr 27;27(9):2781.
