744218-20-0
744218-20-0
Chemical Structure
Declovanillobiocin
- CAS No.: 744218-20-0
- Formula:C31H32N2O12
- Molecular Weight:624.59
InChIKey: JURYCYSCKRZQLD-YYZJCXNBSA-N
SMILES: OC(C1=CC=C(O[C@H]2[C@@H]([C@@H]([C@H](C(C)(O2)C)OC)OC(C3=CC=C(C)N3)=O)O)C=C1O4)=C(NC(C5=CC(OC)=C(C=C5)O)=O)C4=O
Biological Activity: Declovanillobiocin is an aminocoumarin antibacterial agent that competitively binds to the ATP site of the DNA gyrase B subunit, blocking ATP-dependent DNA supercoiling and thereby inhibiting bacterial growth. Declovanillobiocin can be used in research on bacterial infections[1][2].
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Declovanillobiocin | Declovanillobiocin is an aminocoumarin antibacterial agent that competitively binds to the ATP site of the DNA gyrase B subunit, blocking ATP-dependent DNA supercoiling and thereby inhibiting bacterial growth. Declovanillobiocin can be used in research on bacterial infections. | |||||||||||||||||||||
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References
- [1]. Li SM, et al. New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Current medicinal chemistry. 2005;12(4):419-27.
- [2]. Freitag A, et al. New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976. The Journal of antibiotics. 2004 Mar;57(3):205-9.
