Declovanillobiocin
Declovanillobiocin is an aminocoumarin antibacterial agent that competitively binds to the ATP site of the DNA gyrase B subunit, blocking ATP-dependent DNA supercoiling and thereby inhibiting bacterial growth. Declovanillobiocin can be used in research on bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 744218-20-0
- Formula: C31H32N2O12
- Molecular Weight:624.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Declovanillobiocin (at different doses; 30 min (dry); overnight) exhibited lower antibacterial activity against Bacillus subtilis ATCC 14893 than vanillobiocin (HY-N21934) and isovanillobiocin (HY-187850), confirming the contribution of the chlorine atom to antibacterial activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 744218-20-0
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Molecular Weight 624.59
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Formula C31H32N2O12
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SMILES
OC(C1=CC=C(O[C@H]2[C@@H]([C@@H]([C@H](C(C)(O2)C)OC)OC(C3=CC=C(C)N3)=O)O)C=C1O4)=C(NC(C5=CC(OC)=C(C=C5)O)=O)C4=O
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Structure Classification
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Initial Source
Streptomyces roseochromogenes DS12.976
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Aerobic Bacterial Batch Culture on Broth/Agar
Aerobic bacterial batch culture grows a closed inoculated population in broth or on agar without continuous medium replacement; growth readouts include turbidity/OD for total suspended biomass and colony-forming units for viable cells able to form colonies on agar. OD-based growth curves reflect light scattering by cells, but OD is instrument-, pathlength-, species-, cell-size-, and density-dependent, so OD should be calibrated or interpreted alongside viable counts when quantitative cell density is required.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Declovanillobiocin Related Classifications
HY-N21897 Related Classifications
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