74480-23-2
Chemical Structure
AH22921
- CAS No.: 74480-23-2
- Formula:C29H35NO5
- Molecular Weight:477.59
IUPAC Name: (E)-7-((1S,2S,5R)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-morpholino-3-oxocyclopentyl)hept-5-enoic acid
InChIKey: UWQXOMOFJWMVPM-LKFJTKQKSA-N
SMILES: OC(CCC/C=C\C[C@H]1[C@H](N2CCOCC2)C(C[C@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3)=O)=O
Biological Activity: AH22921 is an EP4 prostaglandin receptor antagonist with the activity of antagonizing the activation of adenylate cyclase by prostaglandins in CHO cells. AH22921 can shift the PGE2 concentration-response curve to the right in CHO cells. It is a non-competitive antagonist that is selective for EP4 receptors and has an antagonistic effect on EP4 receptors in CHO cells, but does not affect the PGE2 concentration-response curve in NPE cells containing EP2 receptors.
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AH22921 | AH22921 is an EP4 prostaglandin receptor antagonist with the activity of antagonizing the activation of adenylate cyclase by prostaglandins in CHO cells. AH22921 can shift the PGE2 concentration-response curve to the right in CHO cells. It is a non-competitive antagonist that is selective for EP4 receptors and has an antagonistic effect on EP4 receptors in CHO cells, but does not affect the PGE2 concentration-response curve in NPE cells containing EP2 receptors. | |||||||||||||||||||||
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