74509-14-1
Chemical Structure
Pyrraline
- CAS No.: 74509-14-1
- Formula:C12H18N2O4
- Molecular Weight:254.28
IUPAC Name: (S)-2-amino-6-(2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl)hexanoic acid
InChIKey: VTYFITADLSVOAS-NSHDSACASA-N
SMILES: C1=C(N(C(=C1)C=O)CCCC[C@@H](C(=O)O)N)CO
Biological Activity: Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pyrraline | 99.61% | Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers. | ||||||||||||||||||||
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References
- [1]. Hu C, et al. Untargeted metabolite profiling of serum in rats exposed to pyrraline. Food Sci Biotechnol. 2023 Jan 26;32(11):1541-1549. [Content Brief]
- [2]. Raupbach J, et al. The Effect of Free and Protein-Bound Maillard Reaction Products N-ε-Carboxymethyllysine, N-ε-Fructosyllysine, and Pyrraline on Nrf2 and NFκB in HCT 116 Cells. Mol Nutr Food Res. 2023 Sep;67(18):e2300137. [Content Brief]
