750522-61-3
750522-61-3
Chemical Structure
NSC309401
- CAS No.: 750522-61-3
- Formula:C17H16N6
- Molecular Weight:304.35
InChIKey: LNEWNMFMWDBAKM-UHFFFAOYSA-N
SMILES: NC(C=C1)=CC=C1CN2C=CC3=C4C(N=C(N)N=C4N)=CC=C32
Biological Activity: NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM)[1].
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NSC309401 | NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM). | |||||||||||||||||||||
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References
- [1]. Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282(10):1922-38. [Content Brief]
Keywords
