75207-14-6
Chemical Structure
Monocillin IV
- CAS No.: 75207-14-6
- Formula:C18H22O5
- Molecular Weight:318.36
InChIKey: WSBASKMWDAUNEI-OGOUPESXSA-N
SMILES: OC1=C2C(CC(CCCC/C=C/C[C@H](OC2=O)C)=O)=CC(O)=C1
Biological Activity: Monocillin IV is a macrolide with antibacterial and anti-HIV-1 activities, originally isolated and identified from the metabolites of Monocillium nordinii. Monocillin IV is an inhibitor of HIV-1 Tat protein transactivation, with an IC50 of 5.0 µM. Monocillin IV inhibits HIV-1 viral replication by blocking the Tat transactivation pathway. Monocillin IV exhibits moderate antibacterial activity, with an MIC of 25.6 µg/mL against Xanthomonas campestris pv. campestris . Monocillin IV can be used for research on black rot and HIV-1 infection[1][2][3][4].
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Monocillin IV | Monocillin IV is a macrolide with antibacterial and anti-HIV-1 activities, originally isolated and identified from the metabolites of Monocillium nordinii. Monocillin IV is an inhibitor of HIV-1 Tat protein transactivation, with an IC50 of 5.0 µM. Monocillin IV inhibits HIV-1 viral replication by blocking the Tat transactivation pathway. Monocillin IV exhibits moderate antibacterial activity, with an MIC of 25.6 µg/mL against Xanthomonas campestris pv. campestris . Monocillin IV can be used for research on black rot and HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Qin F, et al. Antibacterial Radicicol Analogues from Pochonia chlamydosporia and Their Biosynthetic Gene Cluster. J Agric Food Chem. 2019;67(26):7266-7273.
- [2]. Li Z, et al. Nematicidal glycosylated resorcylic acid lactones from the fungus Pochonia chlamydosporia PC-170 and their key biosynthetic genes. Front Microbiol. 2024;15:1385255.
- [3]. Gao J, et al. Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors. Journal of natural products. 2013 May 24;76(5):824-8. [Content Brief]
- [4]. Jayasuriya H, et al. Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivation. Chemistry & biodiversity. 2005 Jan;2(1):112-22.
