75272-39-8
Chemical Structure
Nemonapride
Synonym(s): YM-09151-2; Emonapride
- CAS. Nr.: 75272-39-8
- Formula:C21H26ClN3O2
- Molecular Weight:387.90
IUPAC Name: N-((2R,3R)-1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
InChIKey: KRVOJOCLBAAKSJ-RDTXWAMCSA-N
SMILES: O=C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(NC)C=C3OC
Biological Activity: Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals[1][2][3].
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Nemonapride | 99.9% | Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. | ||||||||||||||||||||
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- [1]. Terai M, et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn J Pharmacol. 1983 Aug;33(4):749-55. [Content Brief]
- [2]. Seeman P, Van Tol HH. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. [Content Brief]
- [3]. Assié MB, et al. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur J Pharmacol. 1997 Sep 10;334(2-3):141-7. [Content Brief]
Keywords
