7533-40-6
7533-40-6
Chemical Structure
L-Leucinol
Synonym(s): (+)-Leucinol
- CAS No.: 7533-40-6
- Formula:C6H15NO
- Molecular Weight:117.19
IUPAC Name: (S)-2-amino-4-methylpentan-1-ol
InChIKey: VPSSPAXIFBTOHY-LURJTMIESA-N
SMILES: CC(C)C[C@H](N)CO
Biological Activity: L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with a Ki value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex[1][2].
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L-Leucinol | 99.46% | L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with a Ki value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-W012888D-Leucinol -
Similarity Score 0.84
HY-30167D-Valinol -
Similarity Score 0.84
HY-30167AL-Valinol -
Similarity Score 0.82
HY-W015875(2S,3S)-2-amino-3-methylpentan-1-ol -
Similarity Score 0.79
HY-W1142554-Methylpentan-2-amine hydrochloride -
Similarity Score 0.79
HY-W013029R(S)-2-Aminobutan-1-ol (Standard) -
Similarity Score 0.79
HY-W013031Ethambutol impurity 1 -
Similarity Score 0.78
HY-N0486S5L-Leucine-2-13C -
Similarity Score 0.78
HY-N0486S6L-Leucine-2-13C,15N -
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References
- [1]. Bienvenue DL, et al. Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinethiol: kinetic and spectroscopic characterization of a slow, tight-binding inhibitor-enzyme complex. J Inorg Biochem. 2000;78(1):43-54. [Content Brief]
- [2]. Hao S, et al. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science. 2005;307(5716):1776-1778. [Content Brief]
