761437-28-9
761437-28-9
Chemical Structure
NVP-TAE 226
Synonym(s): TAE226
- CAS No.: 761437-28-9
- Formula:C23H25ClN6O3
- Molecular Weight:468.94
IUPAC Name: 2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
InChIKey: UYJNQQDJUOUFQJ-UHFFFAOYSA-N
SMILES: O=C(C1=C(C=CC=C1)NC2=NC(NC3=C(C=C(C=C3)N4CCOCC4)OC)=NC=C2Cl)NC
Biological Activity: NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NVP-TAE 226 | 99.77% | NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively. | ||||||||||||||||||||
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NVP-TAE 226 (Standard) | ≥98% | NVP-TAE 226 (Standard) is the analytical standard of NVP-TAE 226. This product is intended for research and analytical applications. NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.80
HY-173406RSK-IN-2 -
Similarity Score 0.77
HY-B0792CZC-54252 -
Similarity Score 0.76
HY-B0792ACZC-54252 hydrochloride -
Similarity Score 0.72
HY-15985ACTX-0294885 hydrochloride -
Similarity Score 0.72
HY-15985CTX-0294885 -
Similarity Score 0.72
HY-183120EGFR T790M/FAK-IN-2 -
Similarity Score 0.70
HY-13917PND-1186 -
Similarity Score 0.69
HY-183946NVP-TAC544 -
Similarity Score 0.69
HY-13917APND-1186 hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Liu TJ, et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther, 2007, 6(4), 1357-1367. [Content Brief]
- [2]. Delimont D, et al. Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One. 2014 Jun 10;9(6):e99083. [Content Brief]
