763926-98-3
763926-98-3
Chemical Structure
ORM-10962
- CAS No.: 763926-98-3
- Formula:C27H29N3O4
- Molecular Weight:459.54
IUPAC Name: 2-(4-hydroxypiperidin-1-yl)-N-(6-((2-phenylchroman-6-yl)oxy)pyridin-3-yl)acetamide
InChIKey: UPGUBLDTYLMRHO-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC2=CC=C3C(CCC(C4=CC=CC=C4)O3)=C2)N=C1)CN5CCC(O)CC5
Biological Activity: ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively. ORM-10962 shows antiarrhythmic effect[1][2][3].
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ORM-10962 | 99.49% | ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively. ORM-10962 shows antiarrhythmic effect. | ||||||||||||||||||||
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References
- [1]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041. [Content Brief]
- [2]. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286. [Content Brief]
- [3]. Kohajda Z, et al. Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue. Front Pharmacol. 2020 Jan 29;10:1632. [Content Brief]
