771479-86-8
Chemical Structure
WLSEAGPVVTVRALRGTGSW
- CAS No.: 771479-86-8
- Formula:C97H152N28O27
- Molecular Weight:2142.42
IUPAC Name: 4'-((6-amino-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3'-methoxy-[1,1'-biphenyl]-4-carbonitrile
SMILES: O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure)[1][2].
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WLSEAGPVVTVRALRGTGSW | 99.91% | WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure). | ||||||||||||||||||||
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References
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[1]. Gu J, et al. Engineered bone marrow mesenchymal stem cell-derived exosomes loaded with miR302 through the cardiomyocyte specific peptide can reduce myocardial ischemia and reperfusion (I/R) injury. Journal of translational medicine. 2024 Feb 17;22(1):168.
[Content Brief] - [2]. McGuire MJ, et al. In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo. J Mol Biol. 2004;342(1):171-182. [Content Brief]
