77327-06-1
Chemical Structure
Didemnin C
- CAS No.: 77327-06-1
- Formula:C52H82N6O14
- Molecular Weight:1015.24
IUPAC Name: (R)-N-((3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-((S)-sec-butyl)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15]dioxa[4,7,10,20]tetraazacyclotricosin-7-yl)-2-((S)-2-hydroxy-N-methylpropanamido)-4-methylpentanamide
InChIKey: ZRSXZCRRAOVIJD-KNKJEZLASA-N
SMILES: CC[C@@H]([C@@H]1[C@@H](O)CC(O[C@@H](C(C)C)C([C@H](C)C(N[C@@H](CC(C)C)C(N2CCC[C@H]2C(N(C)[C@@H](CC3=CC=C(OC)C=C3)C(O[C@H](C)[C@H](NC([C@H](N(C([C@@H](O)C)=O)C)CC(C)C)=O)C(N1)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: Didemnin C is a cyclic depsipeptide. Didemnin C inhibits the proliferation of herpes simplex virus (HSV) and exhibits activity against both RNA viruses and DNA viruses. Didemnin C is cytotoxic to cancer cells. Didemnin C can be used in studies related to herpes simplex virus type 2 infection and cancer[1][2].
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Didemnin C | Didemnin C is a cyclic depsipeptide. Didemnin C inhibits the proliferation of herpes simplex virus (HSV) and exhibits activity against both RNA viruses and DNA viruses. Didemnin C is cytotoxic to cancer cells. Didemnin C can be used in studies related to herpes simplex virus type 2 infection and cancer. | |||||||||||||||||||||
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[1]. Rinehart KL Jr, et al. Didemnins: antiviral and antitumor depsipeptides from a caribbean tunicate. Science. 1981 May 22;212(4497):933-5.
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[2]. Ali MA, et al. Didemnins as marine-derived anticancer agents: mechanistic insights and clinical potential. Med Oncol. 2025 Jan 11;42(2):43.
[Content Brief]
Keywords
