775294-71-8
Chemical Structure
AC-73
- CAS No.: 775294-71-8
- Formula:C21H21NO2
- Molecular Weight:319.40
IUPAC Name: 3-(2-(([1,1'-biphenyl]-4-ylmethyl)amino)-1-hydroxyethyl)phenol
InChIKey: UECKKYNEEBRMIL-UHFFFAOYSA-N
SMILES: OC(CNCC1=CC=C(C2=CC=CC=C2)C=C1)C3=CC=CC(O)=C3
Biological Activity: AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells[1]. AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AC-73 | 99.91% | AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells. AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells. | ||||||||||||||||||||
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Similarity Score 0.69
![[1,1'-Biphenyl]-4-yl(phenyl)methanol (Standard) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w322676r.gif)
HY-W322676R[1,1'-Biphenyl]-4-yl(phenyl)methanol (Standard) -
Similarity Score 0.67
HY-W103960RMirabegron impurity-1 (Standard) -
Similarity Score 0.66
HY-122165ALY-79771 hydrochloride -
Similarity Score 0.66
HY-100230ARML133 hydrochloride (Standard) -
Similarity Score 0.65
HY-79106L-Biphenylalanine -
Similarity Score 0.65
HY-100230ML-133 -
Similarity Score 0.65
HY-B0641RFelbinac (Standard) -
Similarity Score 0.64
HY-16056Arbutamine -
Similarity Score 0.64
HY-W103961Mirabegron impurity 11 -
Explore the MedChemAI to find more analogs
![[1,1'-Biphenyl]-4-yl(phenyl)methanol (Standard) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w322676r.gif)
References
- [1]. Fu ZG, et al. A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells. Oncotarget. 2016 Feb 23;7(8):9429-47. [Content Brief]
- [2]. Spinello I, et al. The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells. Haematologica. 2019 May;104(5):973-985. [Content Brief]
