78822-08-9
Chemical Structure
Kasugamycin sulfate
Synonym(s): Ksg sulfate
- CAS No.: 78822-08-9
- Formula:C14H25N3O9.1/2H2O4S
- Molecular Weight:428.40
SMILES: OS(=O)(O)=O.OC(C(N[C@@H](C[C@@H]1N)[C@@H](C)O[C@]1([H])O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]2O)=N)=O.[1/2]
Biological Activity: Kasugamycin (Ksg) sulfate is an aminoglycoside antibiotic (antibiotic) that binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation. Kasugamycin sulfate binds to the P-site and E-site codon regions in the mRNA channel and interferes with mRNA-tRNA codon-anticodon interactions, thereby destabilizing initiator tRNA binding. Kasugamycin sulfate possesses anti-infective activity. Kasugamycin sulfate is used in research on bacterial translation and Pseudomonas infection[1][2][3][4].
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Kasugamycin sulfate | Kasugamycin (Ksg) sulfate is an aminoglycoside antibiotic (antibiotic) that binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation. Kasugamycin sulfate binds to the P-site and E-site codon regions in the mRNA channel and interferes with mRNA-tRNA codon-anticodon interactions, thereby destabilizing initiator tRNA binding. Kasugamycin sulfate possesses anti-infective activity. Kasugamycin sulfate is used in research on bacterial translation and Pseudomonas infection. | |||||||||||||||||||||
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References
- [1]. Zhang H, et al. Simultaneous determination of kasugamycin and validamycin-A residues in cereals by consecutive solid-phase extraction combined with liquid chromatography-tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2018 Mar;35(3):487-497. [Content Brief]
- [2]. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nature structural & molecular biology. 2006 Oct;13(10):871-8. [Content Brief]
- [3]. Kasuga K, et al. Heterologous production of kasugamycin, an aminoglycoside antibiotic from Streptomyces kasugaensis, in Streptomyces lividans and Rhodococcus erythropolis L-88 by constitutive expression of the biosynthetic gene cluster. Applied microbiology and biotechnology. 2017 May;101(10):4259-4268. [Content Brief]
- [4]. Takeuchi T, et al. Pharmacology of kasugamycin and the efeect on Pseudomonas infection. J Antibiot. 1965;18:107-110.
