789488-77-3
789488-77-3
Chemical Structure
ENMD-1068
- CAS No.: 789488-77-3
- Formula:C15H29N3O2
- Molecular Weight:283.41
IUPAC Name: 6-amino-1-(4-(3-methylbutanoyl)piperazin-1-yl)hexan-1-one
InChIKey: VRZYMMVEALDDBH-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN
Biological Activity: ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].
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ENMD-1068 | ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis. | |||||||||||||||||||||
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References
- [1]. Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9(1):19125. [Content Brief]
- [2]. Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8. [Content Brief]
