79335-75-4
79335-75-4
Chemical Structure
FK-565
- CAS No.: 79335-75-4
- Formula:C22H38N4O9
- Molecular Weight:502.56
IUPAC Name: (2R,6S)-2-amino-6-((R)-4-carboxy-4-heptanamidobutanamido)-7-(((R)-1-carboxyethyl)amino)-7-oxoheptanoic acid
InChIKey: ZRWBSKCFKHSDHD-LVQVYYBASA-N
SMILES: CCCCCCC(N[C@@H](C(O)=O)CCC(N[C@@H](CCC[C@@H](N)C(O)=O)C(N[C@H](C)C(O)=O)=O)=O)=O
Biological Activity: FK-565 is a synthetic immunomodulatory peptide with a nucleotide oligomerization domain-1 (NOD1) ligand. FK-565 can activate macrophages, NK cells, and peritoneal exudative cells, enhancing the innate immune response. FK-565 has antiviral activity against a variety of viruses in vivo, and its effect is achieved through immunomodulation rather than direct viral inhibition. FK-565 can induce mouse models of arteritis and coronary arteritis (Kawasaki disease-like disease) through a NOD1-mediated mechanism. FK-565 can be used for research on viral infections and inflammatory vascular diseases[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FK-565 | 99.88% | FK-565 is a synthetic immunomodulatory peptide with a nucleotide oligomerization domain-1 (NOD1) ligand. FK-565 can activate macrophages, NK cells, and peritoneal exudative cells, enhancing the innate immune response. FK-565 has antiviral activity against a variety of viruses in vivo, and its effect is achieved through immunomodulation rather than direct viral inhibition. FK-565 can induce mouse models of arteritis and coronary arteritis (Kawasaki disease-like disease) through a NOD1-mediated mechanism. FK-565 can be used for research on viral infections and inflammatory vascular diseases. | ||||||||||||||||||||
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Pimelautide | Pimelautide (RP 44102), a desmuramyl peptidolipid, is an adjuvant. Pimelautide shows a LD50 of 410 mg/kg (i.v, mouse). | |||||||||||||||||||||
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Glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine | Glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine (N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine) serves as a substrate for Streptomyces R61 D-alanyl-D-alanine peptidase (DD-peptidase). | |||||||||||||||||||||
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Palmitoyl glutathione | Palmitoyl glutathione (PGSH) is a palmitoylated peptide derivative and a liver-targeted liposome-forming agent. Palmitoyl glutathione can form liposome-like vesicles with cholesterol, which can encapsulate water-soluble solutes. Palmitoyl glutathione can be used in studies related to Acetaminophen (HY-66005)-induced liver necrosis. | |||||||||||||||||||||
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Homo-phytochelatin | Homo-phytochelatin is heavy metal chelator presented in legumes. | |||||||||||||||||||||
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Iso-phytochelatin 2 (Glu) | Iso-phytochelatin 2 Glu is chelating peptide with general structure (γ-Glu-Cys)n-Gly, which is induced by heavy metals in high plants and fungi. | |||||||||||||||||||||
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Livagen | Livagen is a peptide with an activity of inducer with activity that increases the number of nucleolus organizers per cell and the number of nucleoli per cell. Livagen can be used for the research of nucleolus-related cellular processes. | |||||||||||||||||||||
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Phytochelatin 2 (PC2) | Phytochelatin 2, a short phytochelatin, is a key plant peptide binding heavy metals. Phytochelatins are a diverse set of plant compounds that chelate metals, protect against metal toxicity and function in metal homeostasis. | |||||||||||||||||||||
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TriDAP | TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP decreases IκBα levels and increases p65 levels. TriDAP induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection. | |||||||||||||||||||||
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C12-iE-DAP | C12-iE-DAP (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid) is a highly potent and selective NOD1 agonist, with an EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1. C12-iE-DAP activates the NOD1/RIPK2 signaling pathway and its downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling. C12-iE-DAP can be used in studies related to vascular inflammation, tumor metastasis and neuroinflammation. | |||||||||||||||||||||
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Ala-D-γ-Glu-Lys-D-Ala-D-Ala | 99.80% | Ala-D-γ-Glu-Lys-D-Ala-D-Ala is the pentapeptide tail of the peptidoglycan precursor UDPMurNAc-l-Ala-γ-d-Glu-l-Lys(Gly)(5)-d-Ala-d-Ala. | ||||||||||||||||||||
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References
- [1]. Yokota Y, et al. Inhibitory effect of FK-565 alone and in combination with zidovudine on retroviral infection by Friend leukemia virus in mice. J Antibiot (Tokyo). 1988 Oct;41(10):1479-87.
- [2]. Sato Y, et al. Treatment of coxsackievirus B3 myocarditis by immunoactive peptide in an animal model. Clin Immunol Immunopathol. 1992 Oct;65(1):65-9.
- [3]. Sato Y, et al. Effect of immunostimulant therapy on acute viral myocarditis in an animal model. Am Heart J. 1992 Aug;124(2):428-34.
- [4]. Ohashi R, et al. Characterization of a murine model with arteritis induced by Nod1 ligand, FK565: A comparative study with a CAWS-induced model. Mod Rheumatol. 2017 Nov;27(6):1024-1030. [Content Brief]
- [5]. Murata K, et al. Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease. Clin Exp Immunol. 2017 Oct;190(1):54-67.
