79768-40-4
Chemical Structure
11-trans Leukotriene D4
Synonym(s): 11-trans LTD4
- CAS No.: 79768-40-4
- Formula:
- Molecular Weight:496.66
IUPAC Name: (5S,6R,7E,9E,11E,14Z)-6-(((R)-2-amino-3-((carboxymethyl)amino)-3-oxopropyl)thio)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
InChIKey: YEESKJGWJFYOOK-KJGJJCHRSA-N
SMILES: CCCCC/C=C\C/C=C/C=C/C=C/[C@@H](SC[C@H](N)C(NCC(O)=O)=O)[C@@H](O)CCCC(O)=O
Biological Activity: 11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
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11-trans Leukotriene D4 | 11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea. | |||||||||||||||||||||
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Keywords
