79955-36-5
Chemical Structure
Cystemustine
- CAS No.: 79955-36-5
- Formula:C6H12ClN3O4S
- Molecular Weight:257.70
IUPAC Name: 1-(2-chloroethyl)-3-(2-(methylsulfonyl)ethyl)-1-nitrosourea
InChIKey: IUOVOJHLRFQQNS-UHFFFAOYSA-N
SMILES: CS(CCNC(N(N=O)CCCl)=O)(=O)=O
Biological Activity: Cystemustine is a DNA inhibitor (a chloroethyl nitrosourea, CENU). Cystemustine can cause DNA cross-linking, thereby inhibiting the proliferation of tumor cells. Cystemustine can also exert cytotoxic effects by interfering with the cell cycle, inducing cell re-differentiation, and altering phospholipid metabolism. Cystemustine exhibits high anti-tumor activity and a relatively short plasma half-life in mice. Cystemustine can be used for the study of various malignant tumors, including melanoma, glioma, renal cancer, head and neck cancer, and colorectal cancer, etc[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cystemustine | Cystemustine is a DNA inhibitor (a chloroethyl nitrosourea, CENU). Cystemustine can cause DNA cross-linking, thereby inhibiting the proliferation of tumor cells. Cystemustine can also exert cytotoxic effects by interfering with the cell cycle, inducing cell re-differentiation, and altering phospholipid metabolism. Cystemustine exhibits high anti-tumor activity and a relatively short plasma half-life in mice. Cystemustine can be used for the study of various malignant tumors, including melanoma, glioma, renal cancer, head and neck cancer, and colorectal cancer, etc. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Palmer B. Cystemustine INSERM. IDrugs. 1998 May;1(1):129-35. PMID: 18465517. [Content Brief]
- [2]. Martineau-Pivoteau N, et al. Circadian rhythm in toxic effects of cystemustine in mice: relevance for chronomodulated delivery. Int J Cancer. 1996 Nov 27;68(5):669-74. [Content Brief]
- [3]. Buchdahl C, et al. Melanoma-cell toxicity of cystemustine combined with O6-benzyl-N2-acetylguanosine. Melanoma Res. 1998 Apr;8(2):123-30. [Content Brief]
- [4]. Demidem A, et al. Cystemustine induces redifferentiation of primary tumors and confers protection against secondary tumor growth in a melanoma murine model. Cancer Res. 2001 Mar 1;61(5):2294-300. [Content Brief]
- [5]. Morvan D,et al. Melanoma tumors acquire a new phospholipid metabolism phenotype under cystemustine as revealed by high-resolution magic angle spinning proton nuclear magnetic resonance spectroscopy of intact tumor samples. Cancer Res. 2002 Mar 15;62(6):1890-7. [Content Brief]
Keywords
