80394-72-5
80394-72-5
Chemical Structure
Oxanosine
- CAS No.: 80394-72-5
- Formula:C10H12N4O6
- Molecular Weight:284.23
IUPAC Name: 5-amino-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)imidazo[4,5-d][1,3]oxazin-7(3H)-one
InChIKey: PWVUOVPUCZNICU-ZIYNGMLESA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N(C=N2)C(N=C(O3)N)=C2C3=O
Biological Activity: Oxanosine is an antibiotic isolated from the streptomyces MG265-CF34, which has anti-tumor activity. Oxanosine is also a substrate for adenosine deaminase[1][2].
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Oxanosine | Oxanosine is an antibiotic isolated from the streptomyces MG265-CF34, which has anti-tumor activity. Oxanosine is also a substrate for adenosine deaminase. | |||||||||||||||||||||
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References
- [1]. Runhan Yu, et al. Oxanosine monophosphate is a covalent inhibitor of inosine 5’-monophosphate dehydrogenase. Chem Res Toxicol. 2019 Feb 25;32(3):456–466.
- [2]. Papiya Majumdar, et al. Oxanosine is a substrate of adenosine deaminase. Implications for the quest for a toxicological marker for nitrosation activity. Chem Res Toxicol. 2005 Dec;18(12):1830-41. [Content Brief]
