80576-83-6
Chemical Structure
Edatrexate
Synonym(s): CGP 30694
- No. CAS: 80576-83-6
- Formula:C22H25N7O5
- Molecular Weight:467.48
IUPAC Name: (4-(1-(2,4-diaminopteridin-6-yl)butan-2-yl)benzoyl)-L-glutamic acid
InChIKey: FSIRXIHZBIXHKT-MHTVFEQDSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(C(CC2=NC3=C(N)N=C(N)N=C3N=C2)CC)C=C1)=O
Biological Activity: Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck[1][2].
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Edatrexate | Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck. | |||||||||||||||||||||
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References
- [1]. Sirotnak FM, et al. Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors. Cancer Res. 1993 Feb 1;53(3):587-91. [Content Brief]
- [2]. Grant SC, et al. Edatrexate, an antifolate with antitumor activity: a review. Cancer Invest. 1993;11(1):36-45. [Content Brief]
