81428-04-8
81428-04-8
Chemical Structure
Taltrimide
Synonym(s): MY-117
- CAS No.: 81428-04-8
- Formula:C13H16N2O4S
- Molecular Weight:296.34
IUPAC Name: 2-(1,3-dioxoisoindolin-2-yl)-N-isopropylethane-1-sulfonamide
InChIKey: NZKNHIQZWSVJGP-UHFFFAOYSA-N
SMILES: O=S(CCN(C(C1=C2C=CC=C1)=O)C2=O)(NC(C)C)=O
Biological Activity: Taltrimide (MY-117), a lipophilic derivative of Taurine (HY-B0351), strongly inhibits the sodium-independent binding of Taurine to synaptic membranes of brain, the effects on the binding of GABA being less pronounced. Taltrimide exhibits definitive anticonvulsive effects in experimental epilepsy models[1][2][3].
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Taltrimide | Taltrimide (MY-117), a lipophilic derivative of Taurine (HY-B0351), strongly inhibits the sodium-independent binding of Taurine to synaptic membranes of brain, the effects on the binding of GABA being less pronounced. Taltrimide exhibits definitive anticonvulsive effects in experimental epilepsy models. | |||||||||||||||||||||
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References
- [1]. Airaksinen EM, et, al. Biochemical and clinical studies on epileptic patients during two phase I trials with the novel anticonvulsant taltrimide. Epilepsy Res. 1987 Sep;1(5):308-11. [Content Brief]
- [2]. Keränen T, et, al. Effects of taltrimide, an experimental taurine derivative, on photoconvulsive response in epileptic patients. Epilepsia. 1987 Mar-Apr;28(2):133-7. [Content Brief]
- [3]. Kontro P, et, al. Effects of the anticonvulsant taurine derivative, taltrimide, on membrane transport and binding of GABA and taurine in the mouse cerebrum. Neuropharmacology. 1987 Jan;26(1):19-23. [Content Brief]
Keywords
