81810-66-4
Chemical Structure
Quinocetone
- CAS No.: 81810-66-4
- Formula:C18H14N2O3
- Molecular Weight:306.32
IUPAC Name: 2-cinnamoyl-3-methylquinoxaline 1,4-dioxide
InChIKey: IOKWXGMNRWVQHX-VAWYXSNFSA-N
SMILES: O=C(C1=C(C)[N+]([O-])=C2C=CC=CC2=[N+]1[O-])/C=C/C3=CC=CC=C3
Biological Activity: Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage[1][2][3][4].
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Quinocetone | 98.25% | Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage. | ||||||||||||||||||||
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Quinocetone (Standard) | 97.94% | Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage. | ||||||||||||||||||||
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- [1]. Zhao Y, et al. In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi. BMC Vet Res. 2016 Sep 6;12(1):186. [Content Brief]
- [2]. Zhou Y, et al. Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking. Cell Biol Toxicol. 2016 Apr;32(2):141-52. [Content Brief]
- [3]. Yang W, et al. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J Sci Food Agric. 2013 Apr;93(6):1317-25. [Content Brief]
- [4]. Yu M, et al. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats. Food Chem Toxicol. 2014 Jul;69:210-9. doi: 10.1016/j.fct.2014.04.026. Epub 2014 Apr 30. PMID: 24795230. [Content Brief]
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