82-05-3
Chemical Structure
Benzanthrone
- CAS No.: 82-05-3
- Formula:C17H10O
- Molecular Weight:230.26
IUPAC Name: 7H-benzo[de]anthracen-7-one
InChIKey: HUKPVYBUJRAUAG-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=C4C1=CC=CC4=CC=C3)C=CC=C2
Biological Activity: Benzanthrone is an immunotoxic, pro-inflammatory Photosensitizer. Benzanthrone upregulates iNOS, COX-2 and inflammatory cytokines; activates ERK1/2, p38, JNK, AP-1 and NF-κB; inhibits Nrf2; and induces oxidative stress and DNA damage. Upon radiation exposure, Benzanthrone generates singlet oxygen and superoxide anion radicals, induces photohemolysis and lipid peroxidation, and alters the levels of skin xenobiotic enzymes. Benzanthrone exhibits differential genotoxicity in different cell lines. Benzanthrone possesses skin tumor-initiating and promoting activities. Benzanthrone can be used in skin tumor-related studies[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Benzanthrone | 99.69% | Benzanthrone is an immunotoxic, pro-inflammatory Photosensitizer. Benzanthrone upregulates iNOS, COX-2 and inflammatory cytokines; activates ERK1/2, p38, JNK, AP-1 and NF-κB; inhibits Nrf2; and induces oxidative stress and DNA damage. Upon radiation exposure, Benzanthrone generates singlet oxygen and superoxide anion radicals, induces photohemolysis and lipid peroxidation, and alters the levels of skin xenobiotic enzymes. Benzanthrone exhibits differential genotoxicity in different cell lines. Benzanthrone possesses skin tumor-initiating and promoting activities. Benzanthrone can be used in skin tumor-related studies. | ||||||||||||||||||||
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- [1]. Tewari P, et al. Benzanthrone induced immunotoxicity via oxidative stress and inflammatory mediators in Balb/c mice. Immunobiology. 2015;220(3):369-381. [Content Brief]
- [2]. Nagy E, et al. DNA adduct formation and oxidative stress from the carcinogenic urban air pollutant 3-nitrobenzanthrone and its isomer 2-nitrobenzanthrone, in vitro and in vivo. Mutagenesis. 2007;22(2):135-145. [Content Brief]
- [3]. Ramdahl T. Polycyclic aromatic ketones in environmental samples. Environ Sci Technol. 1983 Nov 1;17(11):666-70. [Content Brief]
- [4]. Srivastava LP, et al. Photosensitizing potential of benzanthrone. Food Chem Toxicol. 1990;28(9):653-658. [Content Brief]
- [5]. Dwivedi N, et al. Skin tumorigenic potential of benzanthrone: prevention by ascorbic acid. Food Chem Toxicol. 2013;59:687-695. [Content Brief]
Keywords
