828-06-8
828-06-8
Chemical Structure
3,4-Dihydroxyamphetamine hydrochloride
Synonym(s): α-Methyldopamine hydrochloride; α-MeDA hydrochloride
- CAS 番号: 828-06-8
- Formula:C9H14ClNO2
- Molecular Weight:203.67
IUPAC Name: 4-(2-aminopropyl)benzene-1,2-diol hydrochloride
InChIKey: MCRAZJGRCJLDOI-UHFFFAOYSA-N
SMILES: CC(N)CC1=CC(O)=C(O)C=C1.Cl
Biological Activity: 3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure[1][2][3].
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3,4-Dihydroxyamphetamine hydrochloride | 3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure. | |||||||||||||||||||||
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References
- [1]. Schwaninger AE, et al. Urinary excretion kinetics of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its phase I and phase II metabolites in humans following controlled MDMA administration. Clin Chem. 2011 Dec;57(12):1748-56. [Content Brief]
- [2]. Carvalho M, et al. Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates. Arch Toxicol. 2004 Jan;78(1):16-24. [Content Brief]
- [3]. Waldmeier P, et al. On the role of alpha-methyldopamine in the antihypertensive effect of alpha-methyldopa. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(3):303-14. [Content Brief]
