83356-60-9
83356-60-9
Chemical Structure
Esmolol acid hydrochloride
Synonym(s): ASL-8123 hydrochloride
- CAS No.: 83356-60-9
- Formula:C15H24ClNO4
- Molecular Weight:317.81
IUPAC Name: 3-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)propanoic acid hydrochloride
InChIKey: KIRQRJMXRCCUNZ-UHFFFAOYSA-N
SMILES: O=C(CCC1=CC=C(C=C1)OCC(CNC(C)C)O)O.Cl
Biological Activity: Esmolol acid (ASL-8123) hydrochloride is a weak β-adrenergic receptor antagonist. Esmolol acid hydrochloride inhibits the heart rate and diastolic blood pressure response induced by Isoproterenol (HY-B0468) in a dose-dependent manner and can be used in studies of renal failure[1][2].
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Esmolol acid hydrochloride | Esmolol acid (ASL-8123) hydrochloride is a weak β-adrenergic receptor antagonist. Esmolol acid hydrochloride inhibits the heart rate and diastolic blood pressure response induced by Isoproterenol (HY-B0468) in a dose-dependent manner and can be used in studies of renal failure. | |||||||||||||||||||||
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References
- [1]. J E Shaffer, et al. Beta-adrenoreceptor antagonist potency and pharmacodynamics of ASL-8123, the primary acid metabolite of esmolol. J Cardiovasc Pharmacol. 1988 Feb;11(2):187-92. [Content Brief]
- [2]. J F Flaherty, et al. Pharmacokinetics of esmolol and ASL-8123 in renal failure. Clin Pharmacol Ther. 1989 Mar;45(3):321-7. [Content Brief]
