83661-95-4
83661-95-4
Chemical Structure
FA-Phe-Phe
- CAS No.: 83661-95-4
- Formula:C25H24N2O5
- Molecular Weight:432.47
InChIKey: JAPJOLBDXOXSKE-WQICJITCSA-N
SMILES: OC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(/C=C/C2=CC=CO2)=O)CC3=CC=CC=C3)=O)=O
Biological Activity: FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A[1][2].
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FA-Phe-Phe | FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A. | |||||||||||||||||||||
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References
- [1]. Mayer M, et al. Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy. J Med Chem. 2000 Jun 1;43(11):2093-9. [Content Brief]
- [2]. Ostrowska H, et al. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Commun. 1997 May 29;234(3):729-32. [Content Brief]
