840489-44-3
840489-44-3
Chemical Structure
XEN103
- CAS No.: 840489-44-3
- Formula:C22H23F4N5O2
- Molecular Weight:465.44
IUPAC Name: N-(2-cyclopropylethyl)-6-(4-(5-fluoro-2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide
InChIKey: QMZSSLLJQUFMHM-UHFFFAOYSA-N
SMILES: O=C(C1=NN=C(N2CCN(CC2)C(C3=CC(F)=CC=C3C(F)(F)F)=O)C=C1)NCCC4CC4
Biological Activity: XEN103 is a SCD1 inhibitor, with IC50s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice[1][2].
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XEN103 | XEN103 is a SCD1 inhibitor, with IC50s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice. | |||||||||||||||||||||
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References
- [1]. Zhang Z, et al. Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem. 2013 Jan 24;56(2):568-83. [Content Brief]
- [2]. Meingassner JG, et al. Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands. [Content Brief]
Keywords
