84201-40-1
84201-40-1
Chemical Structure
Oltipraz metabolite M2
- CAS No.: 84201-40-1
- Formula:C10H12N2S2
- Molecular Weight:224.35
IUPAC Name: 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine
InChIKey: MYLBTCQBKAKUTJ-UHFFFAOYSA-N
SMILES: CSC1=C(C)C(SC)=C2N1C=CN=C2
Biological Activity: Oltipraz metabolite M2, an active metabolite of Oltipraz (HY-12519), is an orally active HIF-1α inhibitor. Oltipraz metabolite M2 increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK in high-fat diet (HFD)-fed mice. Oltipraz metabolite M2 can be used for hepatic steatosis and steatohepatitis research[1][2].
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Oltipraz metabolite M2 | Oltipraz metabolite M2, an active metabolite of Oltipraz (HY-12519), is an orally active HIF-1α inhibitor. Oltipraz metabolite M2 increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK in high-fat diet (HFD)-fed mice. Oltipraz metabolite M2 can be used for hepatic steatosis and steatohepatitis research. | |||||||||||||||||||||
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References
- [1]. Lee YH, et al. Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor. Bioorg Med Chem. 2016 Jun 15;24(12):2843-51. [Content Brief]
- [2]. Kim TH, et al. An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK. Br J Pharmacol. 2013 Apr;168(7):1647-61. [Content Brief]
