84484-78-6
84484-78-6
Chemical Structure
Didesmethylsibutramine hydrochloride
Synonym(s): BTS 54-505
- CAS No.: 84484-78-6
- Formula:C15H23Cl2N
- Molecular Weight:288.26
IUPAC Name: 1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutan-1-amine hydrochloride
InChIKey: KHRVYINTXCWNRF-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2(C(CC(C)C)N)CCC2)C=C1.Cl
Biological Activity: Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2].
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Didesmethylsibutramine hydrochloride | 98.54% | Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis. | ||||||||||||||||||||
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Didesmethylsibutramine hydrochloride (Standard) | ≥98% | Didesmethylsibutramine (hydrochloride) (Standard) is the analytical standard of Didesmethylsibutramine (hydrochloride). This product is intended for research and analytical applications. Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis. | ||||||||||||||||||||
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Didesmethylsibutramine-d7 hydrochloride | Didesmethylsibutramine-d7 (BTS 54-505-d7) hydrochloride is deuterium labeled Didesmethylsibutramine hydrochloride. | |||||||||||||||||||||
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References
- [1]. Liu YL, et al. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1245-53. [Content Brief]
- [2]. Scott G, et al. The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. Br J Pharmacol. 1994 Jan;111(1):97-102. [Content Brief]
