845727-63-1
Chemical Structure
Ac-RFAAKAA-COOH
- CAS. Nr.: 845727-63-1
- Formula:C35H57N11O9
- Molecular Weight:775.90
InChIKey: NDOPPUBJZDTGKB-LHDKZUJLSA-N
SMILES: N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O
Biological Activity: Ac-RFAAKAA-COOH is a heptapeptide with one reactive Lys residue. Ac-RFAAKAA-COOH forms stable covalent adducts with isothiocyanates, resulting in peptide depletion over time. Ac-RFAAKAA-COOH acts as a model peptide in direct peptide reactivity assays, where its chemical reactivity is evaluated via fluorescamine-based free amine assays. Ac-RFAAKAA-COOH can be used in studies related to allergic contact dermatitis and skin sensitization[1][2].
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Ac-RFAAKAA-COOH | 99.54% | Ac-RFAAKAA-COOH is a heptapeptide with one reactive Lys residue. Ac-RFAAKAA-COOH forms stable covalent adducts with isothiocyanates, resulting in peptide depletion over time. Ac-RFAAKAA-COOH acts as a model peptide in direct peptide reactivity assays, where its chemical reactivity is evaluated via fluorescamine-based free amine assays. Ac-RFAAKAA-COOH can be used in studies related to allergic contact dermatitis and skin sensitization. | ||||||||||||||||||||
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References
- [1]. Karlsson I, et al. Peptide Reactivity of Isothiocyanates--Implications for Skin Allergy. Sci Rep. 2016;6:21203. Published 2016 Feb 17. [Content Brief]
- [2]. Cho SA, et al. Method for detecting the reactivity of chemicals towards peptides as an alternative test method for assessing skin sensitization potential. Toxicol Lett. 2014;225(1):185-191. [Content Brief]
